Anti-CASP1 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Synthetic peptide corresponding to Mouse Caspase-1 aa 100-200 conjugated to Keyhole Limpet Haemocyanin (KLH).Database link: P29452

Conjugate

Unconjugated

Application Notes

WB: 1 μg/ml; IHC-P: 1 μg/ml;

Alternative Names

CASP1; caspase 1; ICE; Il1bc; caspase-1; p45; CASP-1; IL-1BC; IL-1B converting enzyme; IL-1 beta-converting enzyme; interleukin-1 beta convertase; interleukin 1 beta-converting enzyme; interleukin-1 beta-converting enzyme;

Entrez Gene ID

12362

UniProt ID

P29452

Antigen Description

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Pathway

Amyotrophic lateral sclerosis (ALS); Androgen Receptor Signaling Pathway; Cytokine Signaling in Immune system; Cytosolic DNA-sensing pathway

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More