Anti-CASP10 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to Human Caspase-10 aa 225-525.

Conjugate

Unconjugated

Application Notes

WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000; ICC/IF: 1/100 - 1/1000;

Alternative Names

CASP10; caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine proteas

Entrez Gene ID

843

UniProt ID

Q92851

Antigen Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp--AMC and Asp-Glu-Val-Asp--AMC.Isoform C is proteolytically inactive.

Pathway

Apoptosis; Apoptosis; Apoptosis Modulation and Signaling; Death Receptor Signalling

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More