Anti-CASP4 monoclonal antibody
Mouse anti-Human CASP4 monoclonal antibody for WB, sELISA, ELISA
COA
Specifications
Antibody Isotype
IgG2a
Clone
8H8
Species Reactivity
Human
Immunogen
CASP4 (AAH17839, 1 a.a. ~ 377 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Target
Alternative Names
CASP4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis related cysteine protease; caspase-4; ICE(rel)II; ICH 2; TX; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related c
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Pathway
Apoptosis, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NOD1/2 Signaling Pathway, organism-specific biosystem; Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
Have you cited DCABH-10838 in a publication? Let us know and earn a reward for your research.
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Brito, JLR; Walker, B; et al. MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells. Haematologica-The Hematology Journal 94:78-86(2009).
Hu, Y; Liu, HX; et al. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. BIOCHEMICAL PHARMACOLOGY 85:1007-1017(2013).
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Catalog # DCABH-10838
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