Anti-CASP7 monoclonal antibody

Antibody Isotype

IgG2b

Clone

8-2-22

Species Reactivity

Mouse, Rat, Sheep, Rabbit, Hamster, Dog, Human, Pig, Monkey

Immunogen

Recombinant full length protein corresponding to Human Caspase-7.

Conjugate

Unconjugated

Application Notes

ICC/IF: 5 μg/ml; Flow Cyt: 1μg/10⁶ cells; IHC-P: 5 - 10 μg/ml; WB: 1 μg/ml.

Alternative Names

CASP7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis related cysteine protease; caspase-7; CMH 1; ICE LAP3; MCH3; CASP-7; Lice2 alpha/beta/gamma; caspase 7 isoform delta; apoptotic protease MCH-3; ICE-like apoptotic protease 3; cas

Entrez Gene ID

840

UniProt ID

P55210

Antigen Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp--Gly-217 bond. Overexpression promotes programmed cell death.

Pathway

Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem.

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More