Anti-CASP8 Polyclonal Antibody Knockout Validated
Rabbit Anti-Human CASP8 (Ser217~Asp384) Polyclonal Antibody for WB
COA
Specifications
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to human CASP8 (Ser217~Asp384)
Conjugate
Unconjugated
Applications
Application Notes
Recommended dilution:
WB: 0.5-2 ug/ml; 1:500-2000
Images
HepG2 human hepatocellular carcinoma cell line was stained with rabbit Anti-human CASP8 Polyclonal Antibody or Isotype control antibody, followed by APC-conjugated Anti-rabbit IgG Secondary Antibody . Cells were fixed with 4% paraformaldehyde and permeabilized with 0. 1% Triton X-100.
Knockout Varification: Lane 1: Wild-type Hela cell lysate. Lane 2: CASP8 knockout Hela cell lysate.
Predicted MW: 26-32, 46, 54-62kd, Observed MW: 35kd
Figure. Western Blot.
Sample. Human HepG2 Cells.
Target
Alternative Names
CAP4; FLICE; MACH; MCH5; Cysteinyl Aspartate Specific Proteinases 8; Apoptotic cysteine protease; FADD-homologous ICE/ced-3-like protease; MORT1-associated ced-3 homolog
Entrez Gene ID
UniProt ID
Product Background
Pathway
AGE/RAGE pathway; Activated TLR4 signalling; Activation, myristolyation of BID and translocation to mitochondria; Alzheimers disease; Alzheimers Disease; Apoptosis; Apoptosis Modulation and Signaling; Apoptosis Modulation by HSP70;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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| Product Name | Cat. No. | Applications | Host Species | Datasheet | Price | Add to Basket |
|---|
Liedtke, C; Bangen, JM; et al. Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury. GASTROENTEROLOGY 141:2176-2187(2011).
Zhao, P; Gao, CF; et al. Repeated hepatocyte growth factor neutralizing antibody treatment leads to HGF/SF unresponsiveness in human glioblastoma multiforme cells. CANCER LETTERS 291:209-216(2010).
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Catalog # CABT-L2294
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