Anti-CASP8 polyclonal antibody
Rabbit Anti-Human CASP8 (C-terminal) polyclonal antibody for WB
COA
Specifications
Antibody Isotype
IgG
Species Reactivity
Human, Mouse, Rat
Immunogen
A 16 amino acid peptide located near the carboxy-terminus of human caspase-8 isoform A.
Conjugate
Unconjugated
Applications
Application Notes
Western Blot: 0.5ug/ml
Target
Alternative Names
CASP8; caspase 8, apoptosis-related cysteine peptidase; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic prote
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
Caspase-8 is classified as an initiator caspase and acts as the most upstream trigger of Fas-Receptor (CD95) and tumour necrosis factor receptor 1 (TNFR1) mediated apoptosis. Upon activation, the cell death receptor Fas, links with the adaptor molecule FADD via corresponding death domains (DD). FADD in turn then binds via death effector domains (DEDs) to procaspase-8, which then undergoes oligomerization and autocatalytic activation.Active Caspase-8 is capable of cleaving all other known caspases, and also cleaves the Bcl-2 family member BH3-interacting domain death agonist (BID), along with the Bcl-2 associated protein p28Bap31.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
Have you cited DPABY-173 in a publication? Let us know and earn a reward for your research.
| Product Name | Cat. No. | Applications | Host Species | Datasheet | Price | Add to Basket |
|---|
Zhao, P; Gao, CF; et al. Repeated hepatocyte growth factor neutralizing antibody treatment leads to HGF/SF unresponsiveness in human glioblastoma multiforme cells. CANCER LETTERS 291:209-216(2010).
Ibeagha-Awemu, EM; Lee, JW; et al. Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells. VETERINARY RESEARCH 39:-(2008).
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Catalog # DPABY-173
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