Anti-CDKN1A monoclonal antibody
Mouse anti-Human CDKN1A monoclonal antibody for ICC/IF, WB
COA
Specifications
Antibody Isotype
IgG2a
Clone
HU2143
Species Reactivity
Human
Immunogen
Recombinant fragment within Human p21 aa 1-164. The exact sequence is proprietary.Database link: P42771
Conjugate
Unconjugated
Applications
Application Notes
ICC/IF: 1/100 - 1/1000; WB: 1/500 - 1/3000.
Target
Alternative Names
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); CDKN1; cyclin-dependent kinase inhibitor 1; CAP20; CIP1; P21; p21CIP1; p21Cip1/Waf1; SDI1; WAF1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activat
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Pathway
AKT phosphorylates targets in the cytosol, organism-specific biosystem; AMPK signaling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Bladder cancer, organism-specific biosystem;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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| Product Name | Cat. No. | Applications | Host Species | Datasheet | Price | Add to Basket |
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Grace, MB; Singh, VK; et al. 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis. JOURNAL OF RADIATION RESEARCH 53:840-853(2012).
Riveira-Munoz, E; Ruiz, A; et al. Increased expression of SAMHD1 in a subset of HIV-1 elite controllers. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 69:3057-3060(2014).
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Catalog # DCABH-7892
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