Anti-CDKN1A monoclonal antibody [Biotin]
Mouse anti-Human CDKN1A monoclonal antibody for WB, IP, IHC-P, FC
Specifications
Antibody Isotype
IgG2b
Clone
DQ85
Species Reactivity
Human
Immunogen
Full length human recombinant p21 protein
Conjugate
Biotin
Target
Alternative Names
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); CDKN1; cyclin-dependent kinase inhibitor 1; CAP20; CIP1; P21; p21CIP1; p21Cip1/Waf1; SDI1; WAF1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activat
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Pathway
AKT phosphorylates targets in the cytosol, organism-specific biosystem; AMPK signaling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Bladder cancer, organism-specific biosystem;
Citations
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| Product Name | Cat. No. | Applications | Host Species | Datasheet | Price | Add to Basket |
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| Product Name | Cat. No. | Applications | Host Species | Datasheet | Price | Add to Basket |
|---|---|---|---|---|---|---|
| Mouse IgG2b Isotype Control [Biotin-maleimide] | DAGIC1251 | FC EIA IHC | Mouse |
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Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
Nordborg, C; Aman, P; et al. Cell-type-specific expression of p53 and p21 in giant cell arteritis. APMIS 113:594-599(2005).
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Catalog # DCABH-9913
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