Anti-CDKN1A polyclonal antibody
Rabbit anti-Human CDKN1A polyclonal antibody for ICC/IF, sELISA, WB, IHC-P
COA
Specifications
Antibody Isotype
IgG
Species Reactivity
Rat, Cow, Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 100 to the C-terminus of Human p21.
Conjugate
Unconjugated
Applications
Application Notes
ICC/IF: 5μg/ml; Sandwich ELISA: 0.5μg/ml; WB: 1μg/ml;
Target
Alternative Names
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; cyclin-dependent kinase inhibitor 1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated frag
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Pathway
AKT phosphorylates targets in the cytosol; Adaptive Immune System; AhR pathway; Androgen receptor signaling pathway
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
Have you cited DPABH-13830 in a publication? Let us know and earn a reward for your research.
| Product Name | Cat. No. | Applications | Host Species | Datasheet | Price | Add to Basket |
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Galmarini, CM; Bouchet, BP; et al. A p21/WAF1 mutation favors the appearance of drug resistance to paclitaxel in human noncancerous epithelial mammary cells. INTERNATIONAL JOURNAL OF CANCER 119:60-66(2006).
Bernal-Lopez, MR; Garrido-Sanchez, L; et al. Antioxidized LDL Antibodies Are Associated With Different Metabolic Pathways in Patients With Atherosclerotic Plaque and Type 2 Diabetes. DIABETES CARE 36:1006-1011(2013).
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Catalog # DPABH-13830
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