Anti-IL1B monoclonal antibody [Alexa Fluor® 647]
Mouse anti-Human IL1B monoclonal antibody for ICFC, ELISA, Pr*
COA
Additional Formats Available
Specifications
Antibody Isotype
IgG1
Clone
KL2C-2
Species Reactivity
Mouse, Rat, Human, Rhesus monkey
Immunogen
Recombinant human IL-1 beta
Conjugate
Alexa Fluor 647
Applications
Application Notes
ELISA: 5-10 μg/ml (as a capture antibody)
Target
Alternative Names
IL-1; IL1F2; IL1-BETA
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
IL-1 refers to two proteins, IL-1alpha and IL-1beta which are the products of distinct genes, but which are recognized by the same cell surface receptors. IL-1beta is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T cells. The antibody reacts with human interleukin-1beta (IL-1beta) and baboon IL-1beta. The antibody does not recognize mouse IL-1beta or human IL-1alpha or other cytokines. The antibody can neutralize the bioactivity of natural or recombinant IL-1beta.
Citations
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Pereira, NF; Hansen, JA; et al. Cytokine gene polymorphisms in endemic pemphigus foliaceus: a possible role for IL6 variants. CYTOKINE 28:233-241(2004).
Ursum, J; van der Weijden, MAC; et al. IL10 GGC Haplotype Is Positively and HLA-DQA1*05-DQB1*02 Is Negatively Associated with Radiographic Progression in Undifferentiated Arthritis. JOURNAL OF RHEUMATOLOGY 37:1431-1438(2010).
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Catalog # CABT-WN1222
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