Anti-IL1B monoclonal antibody [Biotin]
Mouse anti-Human IL1B monoclonal antibody for ELISA, Pr*
COA
Additional Formats Available
Specifications
Antibody Isotype
IgG2b
Clone
KL2C-3
Species Reactivity
Mouse, Rat, Human, Rhesus monkey
Immunogen
Recombinant human IL-1 beta
Conjugate
Biotin
Applications
Application Notes
ELISA: 5-10 μg/ml (as a capture antibody)
Target
Alternative Names
IL-1; IL1F2; IL1-BETA
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
IL-1 refers to two proteins, IL-1alpha and IL-1beta which are the products of distinct genes, but which are recognized by the same cell surface receptors. IL-1beta is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T cells. The antibody reacts with human interleukin-1beta (IL-1beta) and baboon IL-1beta. The antibody does not recognize mouse IL-1beta or human IL-1alpha or other cytokines. The antibody can neutralize the bioactivity of natural or recombinant IL-1beta.
Citations
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Nissler, K; Pohlers, D; et al. Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation. ANNALS OF THE RHEUMATIC DISEASES 63:1470-1477(2004).
TSUKADA, J; SAITO, K; et al. TRANSCRIPTION FACTORS NF-IL6 AND CREB RECOGNIZE A COMMON ESSENTIAL SITE IN THE HUMAN PROINTERLEUKIN 1-BETA GENE. MOLECULAR AND CELLULAR BIOLOGY 14:7285-7297(1994).
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Catalog # CABT-WN1224
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