Specifications
Species Reactivity
Mouse, Rat, Human, Rhesus monkey
Immunogen
Recombinant human IL-1 beta
Applications
Application Notes
ELISA: 5-10 μg/ml (as a capture antibody)
Target
Alternative Names
IL-1; IL1F2; IL1-BETA
Product Background
Antigen Description
IL-1 refers to two proteins, IL-1alpha and IL-1beta which are the products of distinct genes, but which are recognized by the same cell surface receptors. IL-1beta is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T cells. The antibody reacts with human interleukin-1beta (IL-1beta) and baboon IL-1beta. The antibody does not recognize mouse IL-1beta or human IL-1alpha or other cytokines. The antibody can neutralize the bioactivity of natural or recombinant IL-1beta.
Citations
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Dolinay, T; Kim, YS; et al. Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 185:1225-1234(2012).
Dhiman, N; Ovsyannikova, G; et al. Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. TISSUE ANTIGENS 72:211-220(2008).