Anti-TP73 polyclonal antibody
Rabbit anti-Human TP73 (aa 11-407) polyclonal antibody for WB, IHC-P, ICC/IF
COA
Specifications
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment, corresponding to a region within amino acids 11-407 of Human p73 (Uniprot ID: O15350).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000; ICC/IF: 1/100 - 1/1000;
Target
Alternative Names
TP73; tumor protein p73; P73; p53-related protein; p53-like transcription factor;
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Pathway
Alpha6-Beta4 Integrin Signaling Pathway; DNA damage response (only ATM dependent); E2F transcription factor network; Hippo signaling pathway
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Holcakova, J; Ceskova, P; et al. The cell type-specific effect of TAp73 isoforms on the cell cycle and apoptosis. CELLULAR & MOLECULAR BIOLOGY LETTERS 13:404-420(2008).
Nenutil, R; Ceskova, P; et al. Differential expression of p73 alpha in normal ectocervical epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY 22:386-392(2003).
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Catalog # DPABH-00843
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