CASP10 blocking peptide

Specificity

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Nature

Synthetic

Tag/Conjugate

Unconjugated

Purity

> 95 % by SDS-PAGE.

Format

Liquid

Buffer

Preservative: 0.02% Sodium Azide Constituents: 0.1% BSA, PBS, pH 7.2

Preservative

0.02% Thimerosal

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. Preservative: 0.02% Sodium Azide Constituents: 0.1% BSA, PBS, pH 7.2

UniProt ID

843

Antigen Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Function

cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; death effector domain binding; protein binding; ubiquitin protein ligase binding;

Synonyms

CASP10; caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2;