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    3. Anti-Human CCR4 (Mogamulizumab) monoclonal antibody, Functional Grade

    Anti-Human CCR4 (Mogamulizumab) monoclonal antibody, Functional Grade Functional Grade

    Human anti-Human CCR4 (Mogamulizumab) monoclonal antibody for Depletion, ELISA, FA, FC

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    Specifications
    Antibody Isotype
    IgG1, κ
    Clone
    KW-0761
    Species Reactivity
    Human
    Immunogen
    Humanization of mouse anti-CCR4 mAb7.
    Conjugate
    Functional Grade
    Applications
    Application Notes
    Recommended concentration:
    FC: ≤ 0.25 μg per 10^6 cells in a volume of 100 μl.
    Images
    Depletes regulatory T cells
    (A) Circulating CD8+ cells, CD4+ cells, CD4+Foxp3+ Tregs, CCR4+ Tregs, and CD8:Treg ratio at baseline and after mogamulizumab administration.
    Depletes regulatory T cells
    (A) Circulating CD8+ cells, CD4+ cells, CD4+Foxp3+ Tregs, CCR4+ Tregs, and CD8:Treg ratio at baseline and after mogamulizumab administration.
    Target
    Alternative Names
    CCR4; chemokine (C-C motif) receptor 4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; C-C chemokine receptor type 4; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4; Mogamulizumab
    Entrez Gene ID
    1233
    UniProt ID
    A0N0Q1
    Citations Publication Publication (1)
    Have you cited CABT-Z630H in a publication? Let us know and earn a reward for your research.
    Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer
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    Customer Reviews
    Brancato, SK; Thomay, AA; et al. Toll-like receptor 4 signaling regulates the acute local inflammatory response to injury and the fibrosis/neovascularization of sterile wounds. WOUND REPAIR AND REGENERATION 21:624-633(2013).
    Duvic, M; Pinter-Brown, L; et al. Correlation of Target Molecule Expression and Overall Response in Refractory Cutaneous T-Cell Lymphoma Patients Dosed with Mogamulizumab (KW-0761), a Monoclonal Antibody Directed Against CC Chemokine Receptor Type 4 (CCR4). BLOOD 120:-(2012).
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    Catalog # CABT-Z630H

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