Anti-Human HER2 (Pertuzumab) monoclonal antibody, Functional Grade Functional Grade
Human anti-Human HER2 (Pertuzumab) monoclonal antibody for FA
COA
Additional Formats Available
Specifications
Antibody Isotype
IgG1
Clone
Pertuzumab
Species Reactivity
Human
Immunogen
Human HER2.
Conjugate
Functional Grade
Images
Functional assay.
In vitro efficacy of T-DM1 combined with pertuzumab on cell proliferation and apoptosis. (a and c) Inhibition of cell growth induced by pertuzumab. (b and d) Caspase 3/7 activity in cells treated with pertuzumab and trastuzumab combination was measured in the presence of EGF.
Blockade of HER2
Immunoblot expression of pHER2 in pertuzumab treated CHO-K6 cells. CHO-K6 cells were treated with pertuzumab, trastuzumab. The expression of (A) total HER2, (B) pY1005, (C) pY1127.
Immunoblot expression of pHER2 in pertuzumab treated CHO-K6 cells. CHO-K6 cells were treated with pertuzumab, trastuzumab. The expression of (A) total HER2, (B) pY1005, (C) pY1127.
Binding of antibody CABT-Z697H to antigen protein
Immobilized human HER2[His] at 2 ug/mL can bind CABT-Z697H, EC50=0.01375 ug/mL.
Immobilized human HER2[His] at 2 ug/mL can bind CABT-Z697H, EC50=0.01375 ug/mL.
Target
Alternative Names
ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-protein kinase erbB-2; CD340; HER 2; Trastuzumab
Entrez Gene ID
UniProt ID
Citations
Publication (2)
Publication (2)
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Catalog # CABT-Z697H
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