Anti-Human HER2 (Trastuzumab) monoclonal antibody, Functional Grade Functional Grade
Human anti-Human HER2 (Trastuzumab) monoclonal antibody for FA
COA
Specifications
Antibody Isotype
IgG1, κ
Clone
4D5-8
Species Reactivity
Human
Immunogen
Human epidermoid carcinoma cells (A431) over-expressing EGFR.
Conjugate
Functional Grade
Images
Functional assay.
(A) Proliferation of BT474 cells in the presence of trastuzumab. Cells were treated with trastuzumab and cell number was measured by cell counting experiments. (B)?Response of BT474 and their trastuzumab-resistant and hypersensitive models to trastuzumab assessed in dose-response experiments by cell counting.
Tumor growth inhibition
SKBR3 cells were incubated with titrations of trastuzumab (e) or enavatuzumab with cross-linking secondary antibody (f) in the presence or absence of a single concentration of the other antibody.
SKBR3 cells were incubated with titrations of trastuzumab (e) or enavatuzumab with cross-linking secondary antibody (f) in the presence or absence of a single concentration of the other antibody.
When antigen is immobilized at 2μg/mL (100 μL/well), the concentration for 50% of maximal effect(EC50) of this product is 0.00526 ug/ml.
Target
Alternative Names
ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-protein kinase erbB-2; CD340; HER 2; Trastuzumab
Entrez Gene ID
UniProt ID
Citations
Publication (2)
Publication (2)
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Catalog # CABT-Z628H
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