Recombinant H. pylori vacA Protein (a.a. 1018-1290) [His, B2M]

Product Overview

A DNA sequence encoding the Helicobacter pylori vacA (a.a. 1018-1290) was expressed with His-B2M tag at the N-terminus.

Target

H.pylori vacA

Nature

Recombinant

Tag/Conjugate

His, B2M

Molecular Weight

43.6 kDa

Alternative Names

H. pylori vacA; Vacuolating cytotoxin A; H. pylori VacA toxin

Purity

> 90% , as determined by SDS-PAGE

Format

Liquid or Lyophilized powder

Concentration

Batch dependent - please inquire should you have specific requirements

Buffer

Tris-based buffer,50% glycerol

Preservative

None

Storage

Store at -20°C

Introduction

Helicobacter pylori is a Gram-negative, microaerophilic bacterium that can inhabit various areas of the stomach, particularly the antrum. It causes a chronic low-level inflammation of the stomach lining and is strongly linked to the development of duodenal and gastric ulcers and stomach cancer. Over 80 percent of individuals infected with the bacterium are asymptomatic. The spiral shaped bacterium Helicobacter pylori is strongly associated with inflammation of the stomach and is also implicated in the development of gastric malignancy. H. pylori is known to cause peptic ulcers and chronic gastritis in human. It is associated with duodenal ulcers and may be involved in development of adenocarcimona and low-grade lymphoma of mucosa associated lymphoid tissue in the stomach.

Antigen Description

All H. pylori strains contain a single chromosomal vacA gene. The intact H. pylori vacA gene encodes a protein about 140 kDa in mass. The genus Helicobacter includes at least 20 different species, but intact vacA genes are present only in H. pylori and H. cetorum, a species isolated from stomachs or fecal contents of marine mammals.

Keywords

Helicobacter pylori; H pylori; vacA