The Omicron variant, with a large number of spike gene mutations was designated a variant of concern (VOC). There is still considerable uncertainty related to the transmissibility, vaccine effectiveness, severity of infection and other properties of the Omicron variant. Preliminary evidence suggests there may be an increased risk of reinfection with Omicron. Creative Diagnostics has been tracking the most up-to-date genomic data of the virus and developing a series of recombinant SARS-CoV-2 variant proteins to support the study of variant.
Mutations in the Spike Protein of Omicron
- 30 changes (A67V, T95I, G142D, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F)
- Three deletions (Δ69-70, Δ143-145, Δ211)
- One insertion (ins214EPE)
Figure Source: Stanford University Coronavirus Database
Product List
| Recombinant SARS-CoV-2 Omicron Variant (B.1.1.529) Protein | |||||
| Cat. No | Protein Name | Expression System | Tag | Mutation Site | |
| DAG-WT549 | NTD | HEK293 cells | His | A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE | Inquiry |
| DAG-WT547 | RBD | HEK293 cells | His | G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H | Inquiry |
| DAG-WT555 | RBD | HEK293 cells | His, Avi | G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H | Inquiry |
| DAG-WT550 | RBD | HEK293 cells | His, Avi, Biotinylated | G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H | Inquiry |
| DAG-WT557 | S1 | HEK293 cells | His | A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H | Inquiry |
| DAG-WT548 | Spike Trimer | HEK293 cells | His | A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F | Inquiry |
| DAG-WT551 | Spike Trimer | HEK293 cells | His, Avi, Biotinylated | A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F | Inquiry |
| DAG-WT553 | S-ECD | Insect cells | His | A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F | Inquiry |
| DAG-WT554 | S-ECD | HEK293 cells | His, Avi | A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F | Inquiry |
| DAG-WT552 | N | E. coli | His | P13L, Δ31-33, R203K, G204R | Inquiry |
| DAG-WT556 | N | HEK293 cells | His | P13L, Δ31-33, R203K, G204R | Inquiry |