Human PMAIP1 peptide

Specificity

Highly expressed in adult T-cell leukemia cell line.

Nature

Synthetic

Tag/Conjugate

Unconjugated

Alternative Names

The BH3 motif is essential for pro-apoptotic activity.

Format

Liquid

Buffer

Preservative: 0.02% Sodium Azide Constituents: 0.1% BSA, PBS, pH 7.2

Preservative

0.02% Sodium Azide

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. Preservative: 0.02% Sodium Azide Constituents: 0.1% BSA, PBS, pH 7.2

UniProt ID

5366

Antigen Description

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Function

protein binding;

Synonyms

PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1; APR; NOXA; protein Noxa; PMA-induced protein 1; immediate-early-response protein APR; adult T cell leukemia-derived PMA-responsive;