Recombinant Human GAD
Human GAD, recombinant protein from HEK293 cells
COA
Target
GAD2
Nature
Recombinant
Tag/Conjugate
His
Purity
> 90% as determined by SDS-PAGE
Format
Liquid
Buffer
20 mM Tris-HCl, pH 8.0, 50% glycerol
Preservative
None
Storage
Store at -20°C
Introduction
Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. GAD uses PLP as a cofactor, In mammals, GAD exists in two isoforms encoded by two different genes - GAD1 and GAD2. These isoforms are GAD67 and GAD65 with molecular weights of 67 and 65 kDa, respectively. GAD1 and GAD2 are expressed in the brain where GABA is used as a neurotransmitter, GAD2 is also expressed in the pancreas.
Keywords
Glutamate decarboxylase; glutamic acid decarboxylase; GAD; GAD65-1; GAD65
Citations
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Boutin, P; Dina, C; et al. GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLOS BIOLOGY 1:361-371(2003).
Coley, AA; Ruffin, VA; et al. IMMUNOCYTOCHEMICAL IDENTIFICATION OF ELECTRONEUTRAL NA(+)-COUPLED HCO3- TRANSPORTERS IN FRESHLY DISSOCIATED MOUSE MEDULLARY RAPHE NEURONS. NEUROSCIENCE 246:451-467(2013).
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