Human VWF (aa 23 - 219)
Human Von Willebrand factor (aa 23 - 219), recombinant protein from E. coli
COA
Target
VWF
Nature
Recombinant
Tag/Conjugate
His
Molecular Weight
23.1 kDa
Purity
> 90% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Buffer
PBS, pH 7.4
Preservative
None
Storage
Store at -20°C
Introduction
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Keywords
von Willebrand factor; VWF
Citations
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Miesbach, W; Krekeler, S; et al. Clinical use of Haemate (R) P in von Willebrand disease: A 25-year retrospective observational study. THROMBOSIS RESEARCH 135:479-484(2015).
Moon, HG; Qin, Z; et al. Matrix protein CCN1 induced by bacterial DNA and CpG ODN limits lung inflammation and contributes to innate immune homeostasis. MUCOSAL IMMUNOLOGY 8:243-253(2015).
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Catalog # DAG-WT2751
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