Recombinant Human ZNT8 [His]
Human Zinc transporter 8, recombinant protein from yeast
COA
Product Overview
Dimeric C terminal domain consisting of amino acids 275-369 [325Trp] and amino acids 275-369 [325Arg] with C-terminal 6-His tag
Nature
Recombinant
Tag/Conjugate
His
Molecular Weight
35 kDa
Alternative Names
SLC30A8, ZnT-8, ZNT8
Purity
> 95% as determined by SDS-PAGE
Format
Liquid
Buffer
20mM Tris-HCl, pH 8.0, 200mM NaCl
Storage
Store it at +4°C for short term. For long term storage, store it at -20°C ~-70°C. Avoid repeated freeze-thaw cycles.
Introduction
Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.
Keywords
SLC30A8; zinc transporter 8; ZnT-8; ZNT8
Citations
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Sorensen, JS; Vaziri-Sani, F; et al. Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years. DIABETES RESEARCH AND CLINICAL PRACTICE 96:204-210(2012).
Andersen, MK; Harkonen, T; et al. Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes. AUTOIMMUNITY 46:251-258(2013).
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Catalog # DAGC025
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