Product Overview
Blocking peptide for anti-Slc30A8 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
Antigen Description
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Function
cation transmembrane transporter activity; protein homodimerization activity; zinc ion binding; zinc ion transmembrane transporter activity;
Synonyms
SLC30A8; solute carrier family 30 (zinc transporter), member 8; zinc transporter 8; zinc transporter ZnT-8; ZNT8; ZnT-8;
Citations
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Winkler, C; Raab, J; et al. Lack of Association of Type 2 Diabetes Susceptibility Genotypes and Body Weight on the Development of Islet Autoimmunity and Type 1 Diabetes. PLOS ONE 7:-(2012).
Salem, SD; Saif-Ali, R; et al. Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study. BMC ENDOCRINE DISORDERS 14:-(2014).