Triiodothyronine (T3) ELISA kit

It has been reported that microRNA-206(miR-206) plays an important role in cancers and could be used as a prognostic biomarker. However, the results are controversial. Therefore, we summarize all available evidence and present a meta-analysis to estimate the prognostic value of miR-206 in various cancers. The relevant studies were collected by searching PubMed, EMBASE, and Web of Science databases until August 21, 2020. Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were applied to explore the association between miR-206 and survival results and clinicopathologic features. Sources of heterogeneity were investigated by subgroup analysis and sensitivity analysis. Publication bias was evaluated using Egger's test. Twenty articles involving 2095 patients were included in the meta-analysis. The pooled HR showed that low miR-206 expression was significantly associated with unfavourable overall survival (OS) (HR=2.03, 95 CI%: 1.53-2.70, P0.01). In addition, we found that low miR-206 expression predicted significantly negative association with tumor stage (III-IV VS. I-II) (OR=4.20, 95% CI: 2.17-8.13, P0.01), lymph node status (yes VS. no) (OR=3.58, 95%: 1.51-8.44, P=0.004), distant metastasis (yes VS. no) (OR=3.19, 95%: 1.07-9.50, P=0.038), and invasion depth (T3+T4 vs. T2+T1) (OR=2.43, 95%: 1.70-3.49, P0.01). miR-206 can be used as an effective prognostic indicator in various cancers. Further investigations are warranted to validate the present results.

Tracing the aging progress of soot particles during transport is highly challenging. An Asian dust event could provide an ideal opportunity to trace the continuous aging progress of long-range-transported soot particles. Here, we collected individual aerosol particles at an inland urban site (T1) and a coastal urban site (T2) in China and a coastal site (T3) in southwestern Japan during an Asian dust event. Microscopic analysis showed that the number fraction of soot-bearing particles was 19 % and 16 % at T1 and T2 in China but surprisingly increased to 56 % at T3 in Japan. The dominant fresh soot (71 %) at T1 became partially embedded (68 %) at T2 and fully embedded (84 %) at T3. These results indicated that the tiny soot particles had lower deposition than other aerosol types and became more aged during the transport from T1 to T3. We quantified soot morphology using the fractal dimension and found an increasing trend of 1.65 at T1, 1.84 at T2, and 1.91 at T3. Furthermore, we found that the morphology compression of the soot aggregations was associated with secondary coating thickness and relative humidity. A unique mixing structure where multi-soot particles scattered in organic coatings instead of the sulfate core in individual core-shell particles was observed at T3 after the crossing of the East China Sea. The study provides understanding for important constraints of the soot morphological effects and provides a possible aging scale along with their transport pathway. These new findings will be helpful to improve optical calculations and regional climate modeling of soot particles during their transport in the atmosphere.