Anti-Human TSH polyclonal antibody

Background: Subclinical hypothyroidism (SCH) is a biochemical disease which is characterized by elevated serum levels of thyroid stimulating hormone (TSH) with normal thyroid hormone levels. In an attempt to correct the disease at its entry point, we wished to find out the incidence of subclinical hypothyroidism in female college students in Kumbakonam, a semiurban town of India. Methods: Around 260 female college students who had no history of thyroid disease were screened for thyroid dysfunction by a TSH assay. Results: The mean age +/- standard deviation was 18.72 +/- 2.27 years. The mean TSH value was 3.98 mIU/mL. The incidence of abnormally high TSH values was around 11.5%. The number of such cases was 30 with low T3 values in six students. One had a value of 150 with no symptoms. Another student had a value of 0.15 and her T3-T4 profile was normal. All students were asymptomatic. None of the students had goiter. Conclusions: In an unpublished but accepted study, we found an incidence of 3.5% in the school female children in the age group of 15-17. A sudden jump in the incidence is occurring in the age group of 18-22. This needs a workup of the causative factors and their possible correction.

Purpose. To investigate the association between high-normal preconception TSH levels and reproductive outcomes in infertile women undergoing the first single fresh D5 blastocyst transfer.Methods. This was a retrospective study. Euthyroid patients undergoing the first single fresh D5 blastocyst transfer from January 2018 to May 2019 were initially included. The patients were divided into a low TSH (0.27-2.5 mIU/L) group and a high-normal TSH (2.5-4.2 mIU/L) group. The reproductive outcomes were compared between the groups.Results. A total of 824 women were ultimately included, 460 of whom had serum TSH levels less than 2.5 mIU/L and 364 of whom had serum TSH levels between 2.5 and 4.2 mIU/L. The patients were highly homogeneous in terms of general characteristics. High-normal TSH levels had no adverse impact on the clinical pregnancy rate, miscarriage rate, or live birth rate (respectively, aOR = 0.84, 0.65, 0.61, andP=0.234, 0.145, 0.083). No significant differences were observed in terms of gestational age, single live birth rates, birth weight, or birth length.Conclusion. High-normal TSH levels did not significantly influence reproductive outcomes in infertile women undergoing the first single fresh D5 blastocyst transfer. Further studies are needed to test whether the results might be applicable to a wider population.