Anti-Human VEGF (Aflibercept) monoclonal antibody, Functional Grade Functional Grade
Human anti-Human VEGF (Aflibercept) monoclonal antibody for FA
COA
Specifications
Antibody Isotype
IgG1
Clone
Aflibercept
Species Reactivity
Human
Immunogen
Human VEGF.
Conjugate
Functional Grade
Images
Immunoprecipitation.
(A) Human RPE cell extracts were applied with aflibercept- or normal IgG-immobilized protein G beads. A single protein band around 14 kDa was detected (arrow). (B) Co-IP of human RPE cell extracts using aflibercept was performed, followed by SDS-PAGE and immunoblot (IB) analyses for galectin-1.
Western Blotting.
All tested VEGF-A-binding agents (aflibercept, ranibizumab or bevacizumab) completely restored claudin-1 whereas the chimeric antibody rituximab, used as a control to confirm specificity, did not.
ELISA
Binding properties to VEGF. Binding to VEGF in ELISA for titrated amounts (1000–0.5?ng/mL) of aflibercept at D0 (black) and D7 (blue).
Binding properties to VEGF. Binding to VEGF in ELISA for titrated amounts (1000–0.5?ng/mL) of aflibercept at D0 (black) and D7 (blue).
Target
Alternative Names
VEGF; vascular endothelial growth factor ; vascular endothelial growth factor , VEGF; vascular permeability factor
Citations
Publication (3)
Publication (3)
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Schmid, BC; Oehler, MK; et al. New perspectives in ovarian cancer treatment. MATURITAS 77:128-136(2014).
Falchook, GS; Wheler, JJ; et al. Dual antiangiogenic inhibition: a phase I dose escalation and expansion trial targeting VEGF-A and VEGFR in patients with advanced solid tumors. INVESTIGATIONAL NEW DRUGS 33:215-224(2015).
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