Tag/Conjugate
Unconjugated
Alternative Names
The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.
Purity
> 95 % by SDS-PAGE.
Buffer
Preservative: None Constituents: 50% Glycerol, 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Preservative: None Constituents: 50% Glycerol, 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
Antigen Description
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrands disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Function
chaperone binding; collagen binding; glycoprotein binding; identical protein binding; immunoglobulin binding; integrin binding; protease binding; protease binding; protein N-terminus binding; protein binding; protein homodimerization activity;
Synonyms
VWF; von Willebrand factor; VWD; F8VWF; coagulation factor VIII VWF;
Citations
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Luan, Y; Ding, W; et al. Bone marrow-derived mesenchymal stem cells protect against lung injury in a mouse model of bronchopulmonary dysplasia. MOLECULAR MEDICINE REPORTS 11:1945-1950(2015).
Kusuma, GD; Manuelpillai, U; et al. Mesenchymal stem cells reside in a vascular niche in the decidua basalis and are absent in remodelled spiral arterioles. PLACENTA 36:312-321(2015).