Specifications
Species Reactivity
Mouse, Rat, Sheep, Rabbit, Hamster, Cow, Dog, Human, Pig, Xenopus laevis, Monkey
Immunogen
Full length protein corresponding to Human Superoxide Dismutase 1 aa 1-154.Sequence: MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHE FGDNTAGCTSA GPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADV SIEDSVISLSGDHCIIGRTLVVH EKADDLGKGGNEESTKTGNAGSRLA CGVIGIAQ Database l
Target
Alternative Names
SOD1; superoxide dismutase 1, soluble; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; superoxide dismutase [Cu-Zn]; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; epididymis secretory protein Li 44;
Product Background
Antigen Description
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Pathway
AGE/RAGE pathway; Amyotrophic lateral sclerosis (ALS); Cellular responses to stress; Dopamine metabolism
Citations
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Rafalowska, J; Sulejczak, D; et al. Diverse Expression of Selected SMN Complex Proteins in Humans with Sporadic Amyotrophic Lateral Sclerosis and in a Transgenic Rat Model of Familial Form of the Disease. PLOS ONE 9:-(2014).
Bros-Facer, V; Krull, D; et al. Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1(G93A) mouse model of Amyotrophic lateral sclerosis. HUMAN MOLECULAR GENETICS 23:4187-4200(2014).