Anti-alpha + beta Synuclein monoclonal antibody
Mouse anti-Human alpha + beta Synuclein monoclonal antibody for ICC/IF, IHC-FoFr, WB, IP, IHC-P
COA
Specifications
Antibody Isotype
IgG2a
Clone
Tzo 313
Species Reactivity
Human
Immunogen
This antibody was raised using recombinant alpha and beta synucleins (Human).
Conjugate
Unconjugated
Target
Alternative Names
SNCB; synuclein, beta; beta-synuclein;
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson's disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson's disease, Alzheimer's disease and several other neurodegenerative illnesses.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Vivacqua, G; Casini, A; et al. Different sub-cellular localization of alpha-synuclein in the C57BL\6J mouse's central nervous system by two novel monoclonal antibodies. JOURNAL OF CHEMICAL NEUROANATOMY 41:97-110(2011).
Fares, MB; Ait-Bouziad, N; et al. The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells. HUMAN MOLECULAR GENETICS 23:4491-4509(2014).
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Catalog # DCABH-8221
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