Anti-alpha + beta Synuclein monoclonal antibody
Rabbit anti-Human alpha + beta Synuclein monoclonal antibody for FC, WB, ICC/IF
Specifications
Antibody Isotype
IgG
Clone
FQ2757Z
Species Reactivity
Mouse, Rat, Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human alpha Synuclein aa 1-100 (N terminal).
Conjugate
Unconjugated
Applications
Application Notes
Flow Cyt: 1/1000; WB: 1/50000; ICC/IF: 1/50 - 1/100.
Target
Alternative Names
SNCB; synuclein, beta; beta-synuclein;
Entrez Gene ID
UniProt ID
Product Background
Antigen Description
Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson's disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson's disease, Alzheimer's disease and several other neurodegenerative illnesses.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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| Product Name | Cat. No. | Applications | Host Species | Datasheet | Price | Add to Basket |
|---|---|---|---|---|---|---|
| Rabbit IgG Isotype Control | CABT-B8382 | IA | Rabbit |
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Bennett, DA; Schneider, JA; et al. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. NEUROLOGY 64:834-841(2005).
Meulener, MC; Graves, CL; et al. DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. JOURNAL OF NEUROCHEMISTRY 93:1524-1532(2005).
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Catalog # DCABH-9033
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